General Cell Based Assays
Cayman Chemical Phagocytosis Assay Kit (IgG-DyLight™ 633), 1 ea
Cayman’s Phagocytosis Assay Kit (IgG-DyLight™ 633) employs latex beads coated with fluorescently-labeled rabbit IgG as a probe for the measurement of the phagocytic process in vitro. The engulfed fluorescent beads can be detected using a fluorescence microscope, allowing kinetic studies of phagocytosis at the single-cell level. In addition, the flow cytometric readout provides the advantage of visualizing perturbations in phagocytosis on the population level and, when combined with antibody staining, of specific cell types within complex populations. This kit provides enough Latex Beads-Rabbit IgG-DyLight™ 633 Complex for up to 500 samples.
Eurofins Discoverx PathHunter eXpress CHRM4 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0349E2CP0L)
The PathHunter CHRM4 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. acetylcholine) based activation of CHRM4 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CHRM4 and EA-tagged β-Arrestin-2. Activation of CHRM4 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress IL17RA/IL17RC Dimerization Assay, 10pl Kit. (93-0999E3CP0L)
The PathHunter IL17RA/IL17RC (U2OS) Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-17a) induced dimerization of IL17RA/IL17RC (U2OS) receptors. This product uses EFC technology. The cell line included overexpresses IL17RC target protein fused to PK alongside IL17RA target protein fused to EA. Upon ligand-induced dimerization of IL17RA/IL17RC, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx AssayComplete Cell Plating 19 Reagent, 100. (93-0563R19A)
AssayComplete Cell Plating 19 Reagent is an optimized cell plating reagent for use in plating of Eurofins DiscoverX cell lines for assays. This reagent was optimized for maximal cell health and ligand responsiveness during assays while eliminating hormones and growth components which may lead to increased basal activity. This product is provided as a bottle of 100 mL. Please refer to cell line specific datasheet to determine the recommended cell plating reagent. For detailed product information, User manual and datasheet, visit www.discoverx.com/reagents.
Eurofins Discoverx PathHunter eXpress GPR37 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0339E2ACP1L)
The PathHunter GPR37 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR37 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR37 and EA-tagged β-Arrestin-2. Activation of GPR37 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Meso Scale Discovery U-PLEX Human MCP-2 ASY 25 PL
The Meso Scale Discovery U-PLEX Human MCP-2 Assay is a multiplex immunoassay kit that enables simultaneous quantitative measurement of the human chemokine MCP-2 It utilizes MSD s proprietary electrochemiluminescent detection technology and is provided in a convenient all-in-one kit containing plates coated with capture antibodies detection antibodies calibrators and buffers The assay has high sensitivity and wide dynamic range requires low sample volume and provides rapid results It is intended for research use only to monitor MCP-2 levels in cell culture supernatants serum plasma and other biological samples
ACROBiosystems Human Fc gamma RIIIA / CD16a (V176) binding Kit (TR-FRET) is expressed from Human, 100 tests
Human Fc gamma RIIIA / CD16a (V176) binding Kit (TR-FRET) is expressed from Human
Cayman Chemical LipidLaunch™ LNP-0315 Uptake Kit (Near-Infrared Fluorescence), 1 ea
Cayman’s LipidLaunch™ LNP-0315 Uptake Kit (Near-Infrared Fluorescence) is intended to serve as a starting point for laboratories to explore the uptake of LNPs in vivo without the need for specialized equipment. Optimal preparation conditions for the encapsulation of nucleic acids with LNPs must be determined by the end user.
Indigo Biosciences INDIGO BIOSCIENCES Human FGFR4 Reporter Assay System, 1 x 384-well format, FGFR4/α-Klotho
This reporter assay system uses proprietary human cells expressing Human Fibroblast Growth Factor Receptor 4 and α-Klotho (FGFR4/α-Klotho) to quantify luciferase activity for screening functional interactions.
- Utilizes proprietary human cells engineered for constitutive expression of human fibroblast growth factor receptor 4
- Exploits signal transduction via the Ca+2·calcineurin / NFAT cascade
- Quantifies relative changes in luciferase activity for dose-dependent measure
- All-inclusive cell-based reporter assay system with cryopreserved cells for immediate dispensing
Abcam DNMT3B Assay Kit.
DNMT3B Assay Kit.
The product is subject to the following: Abcam Restricted Use Statement
ACROBiosystems Human Fc gamma RIIIA / CD16a (F176) binding Kit (TR-FRET) is expressed from Human, 500 tests
Human Fc gamma RIIIA / CD16a (F176) binding Kit (TR-FRET) is expressed from Human
Eurofins Discoverx PathHunter Human HRH4 (H4) β-Arrestin Cell-Based Assay Kit (U2OS)
The PathHunter Human HRH4 (H4) β-Arrestin Stable Cell Line Assay (U2OS) contains a stable clonal cell line used to measure HRH4 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter eXpress PRLR-JAK1 Functional Assay, 2-Plate Kit. (93-0686E3CP0M)
The PathHunter PRLR-JAK1 Functional assay eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting CTKs. This kit assesses PRLR activation via detection of JAK1 mediated phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged PRLR cytokine receptor, an untagged CTK JAK1 and EA-tagged SH2 domain protein. Upon activation of the cytokine receptor, CTK-based receptor phosphorylation leads to SH2-EA recruitment and production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.